A recently published study examined the relationship between total dietary flavonoid intake and the risk of Alzheimer’s disease related dementias (ADRD) using data from the Framingham Offspring cohort. These participants were healthy at the start of the study. Flavonoid intake was updated at each examination and the cumulative average intake for 5 examinations was calculated.
2,801 participants were followed for an average of 19.7 years. 193 cases of ADRD were diagnosed, of which 158 were actual cases of Alzheimer’s disease.
Individuals with the highest intakes of flavonols, anthocyanins, and flavonoid polymers showed a lower risk of ADRD compared to individuals with the lowest intakes (HR: 0.54, 95% CI: 0.32-0.90 for flavonols; HR: 0.24, 95% CI: 0.15-0.39 for anthocyanins; and HR: 0.58, 95% CI: 0.35-0.94 for flavonoid polymers). The same pattern of associations was observed for Alzheimer’s disease in relation to flavonols and anthocyanins, but not for flavonoid polymers.
Shishtar E, Rogers GT, Blumberg JB, Au R, Jacques PF. Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort. Am J Clin Nutr. [published online ahead of print]