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Dear Colleagues and Friends,
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Neuropsychiatric disorder
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Glycolysis/gluconeogenesis and tricarboxylic acid (TCA) cycle metabolites have been associated with type 2 diabetes (T2D). Nevertheless, associations between these metabolites with T2D incidence, as well as the potential effects of dietary interventions remain unclear. 251 patients with incident T2D served as cases and 638 non-cases were included in a nested case-cohort study within the PREDIMED Study. A panel of glycolysis/gluconeogenesis-related metabolites were identified, which were significantly associated with T2D risk within a Mediterranean population at high cardiovascular disease risk. A Mediterranean diet may counteract the detrimental effects of these metabolites.
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A study tested the hypothesis that in addition to the food environment’s direct effect on obesity, the food environment is indirectly associated with obesity through consuming the Mediterranean diet (MD). A total of 20,897 non-Hispanic black and white adults aged ≥45 years old were scored 0-9 on MD adherence and their BMI was calculated. The findings of the study suggest that both, access to healthy food outlets and MD adherence have a significant inverse relationship with BMI. Mediterranean diet adherence mediated the relationship between food environment and obesity among a subpopulation who had an annual household income of <$75 000. Population intervention policies aimed towards modifying the food environment and promoting MD consumption are needed to combat the obesity crisis within the United States.
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