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Epidemiological research
The Effect of the Paleolithic Diet vs. Healthy Diets on Glucose and Insulin Homeostasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Basic research
Improving Stability and Accessibility of Quercetin in Olive Oil-in-Soy Protein Isolate/Pectin Stabilized O/W Emulsion.
The formulation optimization and properties of novel oleuropein-loaded nanocarriers.
Astaxanthin supplementation impacts the cellular HSP expression profile during passive heating.
Domestic Sautéing with EVOO: Change in the Phenolic Profile.
Optimal conditions for olive mill wastewater treatment using ultrasound and advanced oxidation processes.
Changes in gene expression and metabolic profile of drupes of Olea europaea L. cv Carolea in relation to maturation stage and cultivation area.
Novel olive oil phenolic (-)-oleocanthal (+)-xylitol-based solid dispersion formulations with potent oral anti-breast cancer activities.

Observational studies
Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution.
Adherence to Mediterranean diet and subsequent cognitive decline in men with cardiovascular disease.
Dietary Folate Intake and Folic Acid Supplements among Pregnant Women from Southern Italy: Evidence from the "Mamma & Bambino" Cohort.
Physical Education Classes as a Precursor to the Mediterranean Diet and the Practice of Physical Activity.
The Association between Popular Diets and Serum Testosterone among Men in the United States.


Reviews
New Opportunities to Mitigate the Burden of Disease Caused by Traffic Related Air Pollution: Antioxidant-Rich Diets and Supplements.

Summary:
Health benefits associated with the phenolic content of extra virgin olive oil (EVOO) are well known. Its protective role against a wide range of diseases such as diabetes, cancer, cardiovascular or neurodegenerative diseases has led to different lines of research. Two new basic research studies have investigated new formulations of nutraceuticals with polyphenols. One formulation aimed to encapsulate oleuropein and study the process optimization and properties. Solid dispersion formulations of oleocanthal were tried in combination with xylitol for taste-masking. Oleocanthal was identified as the most bioactive olive phenolic and was studied in mice for its potent anti-breast cancer activity with promising results. Another trial was conducted with EVOO to study changes in the phenolic profile when olive oil is cooked at high temperatures. Temperatures of 120ºC to 170ºC decreased antioxidant content and promoted pro-oxidation formation. Nevertheless, polyphenol content continued reducing secondary undesired compounds.

Olive oil is one of the main components of the Mediterranean Diet (MD), widely studied for its cardiometabolic benefits. A recent observational study, which included men with cardiovascular disease, found a relationship between cognitive decline and adherence to MD. The study observed that participants on MD exhibited improved cognitive function compared to those who followed low-fat diets. Furthermore, in relation with antioxidant properties of the MD, a study suggested the adherence to the MD offers an opportunity to mitigate the burden of disease caused by traffic related air pollution.

To sum up, antioxidant properties of extra virgin olive oil and the Mediterranean Diet are being studied extensively for their many health benefits, however these studies indicate more randomized trials are needed to confirm the findings of basic and observational research.

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