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Olive oil

Effects of n-6 PUFA-rich soybean oil, MUFA-rich olive oil and camellia seed oil on weight and cardiometabolic profiles among Chinese women: a 3-month double-blind randomized controlled-feeding trial.

Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases.

Children and adolescents

Early Life Nutrition and the Role of Complementary Feeding on Later Adherence to the Mediterranean Diet in Children up to 3 Years of Age.

Does Adherence to the Mediterranean Diet Have a Protective Effect against Asthma and Allergies in Children? A Systematic Review.

Effectiveness of an Intervention Programme on Adherence to the Mediterranean Diet in a Preschool Child: A Randomised Controlled Trial.

Moderators of Food Insecurity and Diet Quality in Pairs of Mothers and Their Children.

Quality of life related to health and habits: Differences between adolescents in rural and urban environments.

Lifestyle mediates the relationship between self-esteem and health-related quality of life in Chilean schoolchildren.

Women’s health

The Influence of Diet on Ovulation Disorders in Women-A Narrative Review.

Efficacy, Feasibility and Acceptability of a Mediterranean Diet Intervention on Hormonal, Metabolic and Anthropometric Measures in Overweight and Obese Women with Polycystic Ovary Syndrome: Study Protocol.

Mediterranean Diet Combined With a Low-Carbohydrate Dietary Pattern in the Treatment of Overweight Polycystic Ovary Syndrome Patients.

Mediterranean-Style Diet and Risk of Preeclampsia by Race in the Boston Birth Cohort.

Mental health

The benefits of the Mediterranean diet in first episode psychosis patients taking antipsychotics.

Healthy Food Pyramid as Well as Physical and Mental Activity in the Prevention of Alzheimer's Disease.

Mediterranean-Type Diet and Brain Structural Change from 73 to 79 Years in the Lothian Birth Cohort 1936.

The effect of a Mediterranean diet on the symptoms of depression in young males (the "AMMEND" study): A Randomized Control Trial.

Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial.

Cardiovascular disease

Effect of Dietary Phenolic Compounds on Incidence of Cardiovascular Disease in the SUN Project; 10 Years of Follow-Up.

The Lifestyle Profile of Individuals with Cardiovascular and Endocrine Diseases in Cyprus: A Hierarchical, Classification Analysis.

Risk Factors for Coronary Heart Disease Among Lebanese Women: A Case-Control Study.

Digestive system diseases

Dietary patterns and gallstone risks in Chinese adults: a cross-sectional analysis of China Multi-Ethnic Cohort Study.

A Combination of Mediterranean and Low-FODMAP Diets for Managing IBS Symptoms? Ask Your Gut!


Diet impacts triple-negative breast cancer growth, metastatic potential, chemotherapy responsiveness, and doxorubicin-mediated cardiac dysfunction.

Other studies

Adherence to the Mediterranean diet among adults in Mediterranean countries: a systematic literature review.

Evaluating Dietary Patterns in Women from Southern Italy and Western Mexico.
The role of nutrition in inflammaging.


Mediterranean diet contains a large amount of phenolic compounds. Phenolic compounds (secondary plant metabolites) are contained in a wide variety of vegetables, fruits, nuts, seeds, cereals, oils, coffee, chocolate and spices. These compounds show a wide structural diversity and can commonly be grouped into five classes: flavonoids, phenolic acids, stilbenes, lignans, and other polyphenols.

Phenolic compounds favor the elimination of reactive oxygen species. Some of these protective characteristics also have effects on human health, promoting longevity by reducing the incidence of chronic diseases (cancer, diabetes, obesity, and cardiovascular disease). The absorption, transport, bioavailability and bioactivity of polyphenols after food intake vary according to the type of compound. Some of them are absorbed in the stomach, while others, compounds such as catechins, flavanols and flavones, pass directly into the circulatory system through the small intestine. The absorption of phenolic compounds is also linked to microbial activity and digestive enzymes. During its absorption, the interactions of phenolic compounds can modulate potential risk factors for chronic diseases by promoting cardioprotective effects and improving insulin sensitivity.

Due to the importance of these compounds, in a relatively young Mediterranean cohort, the consumption of polyphenols was analyzed in 16,147 Spanish participants on cardiovascular disease for a median of 12.2 years. The results obtained were that a suboptimal intake of phenolic compounds was independently associated with an increased risk of CVD (HR= 1.85 (95% CI: 1.09–3.16)) in the most adjusted model, this study also suggested that a moderate to high dietary intake of phenolic compounds, especially flavonoids, is likely to reduce CVD incidence in the context of a Mediterranean dietary pattern.

In addition to observational studies, a meta-analysis that collected information from clinical trials also provided evidence on the possible cardiovascular benefits of a diet rich in flavonol. On the other hand, a systematic review and meta-analysis of prospective cohort studies found that flavonol intake was inversely associated with CVD risk in US or European populations. In addition, the results of the dose-response analysis indicated that an average increase of 10 mg/day in flavonol intake was associated with a 5% lower risk of CVD.

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