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The Aging Imageomics Study: Rationale, Design and Baseline Characteristics of the Study Population

The Association of Animal and Plant Protein With Successful Ageing: A Combined Analysis of MEDIS and ATTICA Epidemiological Studies

Diet Quality and Risk of Frailty Among Older Women in the Nurses' Health Study


Anticancer Molecular Mechanisms of Oleocanthal

Cardiovascular Disease

Efficacy of Dietary Intervention or in Combination With Exercise on Primary Prevention of Cardiovascular Disease: A Systematic Review


The Effect of a Family-Based Lifestyle Education Program on Dietary Habits, Hepatic Fat and Adiposity Markers in 8-12-Year-Old Children With Overweight/Obesity

Cognitive functioning

Findings of a Pilot Study Investigating the Effects of Mediterranean Diet and Aerobic Exercise on Cognition in Cognitively Healthy Older People Living Independently Within Aged-Care Facilities: The Lifestyle Intervention in Independent Living Aged Care (LIILAC) Study


Complementary Medicine Mention and Recommendations Are Limited Across Hypertension Guidelines: A Systematic Review

Effects of Olive Oil on Blood Pressure: Epidemiological, Clinical, and Mechanistic Evidence

Molecular Biology

Transcriptomic Evidence of Molecular Mechanisms Underlying the Response of Lactobacillus Plantarum WCFS1 to Hydroxytyrosol


Lifestyle-Related Factors and Total Mortality in a Mediterranean Prospective Cohort

Association of a Traditional Mediterranean Diet and non-Mediterranean Dietary Scores with All-Cause and Cause-Specific Mortality: Prospective Findings From the Moli-sani Study

Nutrition and Lifestyle

Evaluation of Adherence to the Mediterranean Diet and Its Association With Clinical and Biological Markers in an Italian Population

Association Between Breast Milk Mineral Content and Maternal Adherence to Healthy Dietary Patterns in Spain: A Transversal Study

Multidimensional Impact of Mediterranean Diet on IBD Patients

Olive Cultivation

New Strategies in the Cultivation of Olive Trees and Repercussions on the Nutritional Value of the Extra Virgin Olive Oil

Proteomics and Metabolomics

Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study

Weight Loss

Exploring the Relationship Between the Mediterranean Diet and Weight Loss Maintenance: The MedWeight Study

Other news

Olive Oil in Packaged Foods Influences Consumers More than Other Fats, Study Shows
Extra Virgin Olive Oil from Jaén Granted PGI Status


This week we bring you two reviews of the health benefits of the consumption of olive oil and extra virgin olive oil. The first review examines the effects of olive oil on blood pressure. Primary or essential hypertension can be broadly defined as the chronic elevation of blood pressure over 130/80 mmHg and affects more than 1 billion people around the world. Olive oil is rich in oleic acid and, to a lesser extent, other compounds such as sterols, tocopherols, carotenoids, and phenolic acids. The first evidence found on the beneficial effects of olive oil on blood pressure dates back to the end of the ‘80s when a group of researchers saw an inverse relationship between the consumption of oleic acid and blood pressure. Since then, a large amount of observational studies and clinical trials have been conducted in different populations and diverse contexts. All of them have robustly confirmed the anti-hypertensive effect of olive oil, explained primarily by its high content of oleic acid and antioxidant polyphenols.

Other health benefits of olive oil consumption have been related to its anti-neoplasic properties. The second review summarizes the anti-cancer activity of the oleocanthal, a phenolic compound found in extra virgin olive oil. Oleocanthal generally represents about 10% of the total phenolic compounds, ranging from 0.2 mg/kg to 498 mg/kg. Substantial evidence supports the activity of oleocanthal in vitro and in vivo against a wide range of different cancers such as colorectal, breast, melanoma, liver, prostate, and carcinoma. Furthermore, it has been observed that the antineoplastic effects of oleocanthal do not affect the non-tumoral cells. Nor does oleocanthal have any toxicity or side effects when consumed alone or combined with chemotherapeutic agents. The review emphasizes the molecular signaling pathways modulated by oleocanthal in different tumor cell types, including anti-inflammatory action, antioxidant activity, modulation of apoptosis, and inhibition of STAT3, and HGF/c-Met signaling pathways. Noteworthy, the antioxidant and anti-inflammatory effects of oleocanthal play a vital role in the inhibition of cancer initiation and progression. Lastly, several studies have demonstrated that the consumption of long-term micro-doses of oleocanthal, characteristic of the Mediterranean pattern, may diminish the body’s inflammatory response over the years, and therefore may reduce the development of chronic inflammatory diseases, including cancer.

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