Osteoporosis is an emerging public health problem and the effects of nutrients on bone health is a particularly important field of research. Evidence from a few studies conducted in humans suggests that olive oil is a protective agent for bone health. Several studies have found that the Mediterranean diet, which is characterized by high intake of fruits, vegetables, and olive oil, is positively associated with better bone health. A recent review evaluates the current evidence on the relationship between the Mediterranean diet, within which olive oil is the main fat, and osteoporosis. The findings confirm the influence of nutrition on osteoporosis and fragility fracture. This review highlights a clinical study with a Mediterranean-like dietary pattern supplemented with 10 μg/day of vitamin D3 which significantly reduced the rate of bone loss at the femoral neck in osteoporotic subjects after one year.