The Mediterranean diet is accompanied by other key aspects of the Mediterranean culture, including an environment which fosters socialization, physical activity, a short nap or “siesta” after meals, traditional recipes, and culinary practices. All these elements and behaviors best characterize the adoption of a traditional Mediterranean lifestyle. Epidemiologic studies have started to evaluate the joint health effect of multiple health behaviors and biological cardiovascular risk factors combined into a single predefined score. In this sense, a Mediterranean lifestyle (MEDLIFE) index score was developed and validated in a Spanish working population and has been used in both Mediterranean and non-Mediterranean populations. In fact, regarding the latter group, a new cross-sectional analysis in 249 US career firefighters showed that a higher adherence to traditional Mediterranean lifestyle habits, as measured by the MEDLIFE index, was associated with a decreased prevalence of metabolic syndrome. Moreover, among the metabolic syndrome components, MEDLIFE was inversely associated with abdominal obesity and hypertriglyceridemia, as well as total cholesterol, LDL cholesterol, and total-c:HDL cholesterol ratio, which favors a more beneficial cardiometabolic profile.