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Mimetics of extra virgin olive oil phenols with anti-cancer stem cell activity


Evaluation of Mediterranean diet adherence in children diagnosed with pancreatitis: a case-control study.

Dietary patterns

Association of carbohydrate quality and all-cause mortality in the SUN Project: A prospective cohort study.

Erectile disfunction

Association of Diet With Erectile Dysfunction Among Men in the Health Professionals Follow-up Study.

Intestinal disease

Exploring the effects of phenolic compounds to reduce intestinal damage and improve the intestinal barrier integrity: A systematic review of in vivo animal studies.


Eating Habits and Lifestyle during COVID-19 Lockdown in the United Arab Emirates: A Cross-Sectional Study.

Health-related quality of life in adolescents: individual and combined impact of health-related behaviors (DADOS study).

Composite Score of Healthy Lifestyle Factors and Risk of Hepatocellular Carcinoma: Findings from a Prospective Cohort Study.

Dietary Patterns, Their Nutrients, and Associations with Socio-Demographic and Lifestyle Factors in Older New Zealand Adults.

Mental health

Gut Health = Mental Health? The Impact of Diet and Dietary Supplements on Mood Disorders.

The Effects of COVID-19 and Quarantine Measures on the Lifestyles and Mental Health of People Over 60 at Increased Risk of Dementia.

Metabolic health

Relationship Among Adherence to The Mediterranean Diet and Anthropometric and Metabolic Parameters in Subjects with Obesity.

Short dietary intervention with olive oil increases brown adipose tissue activity in lean but not overweight subjects.

Olive oil

Olive Oil: Processing Characterization, and Health Benefits.

Two Blends of Refined Rice Bran, Flaxseed, and Sesame Seed Oils Affect the Blood Lipid Profile of Chinese Adults with Borderline Hypercholesterolemia to a Similar Extent as Refined Olive Oil.



The Mediterranean diet (MD) is a primary exposure of interest for numerous studies based on its cardio-protective, anti-diabetic, anti-cancer properties, etc. However, there are other less researched fields, such as the relationship between the MD and the prevention of erectile dysfunction among men. In this study, erectile dysfunction was studied as the main outcome since it is an early sign of cardiovascular disease with serious implications on the quality of life of young adults. This research showed an inverse association between men with high versus low adherence to the MD. More specifically, subjects under 60 years of age had an average risk reduction of 22%, although a significant risk reduction was also observed in men between 60 to 70 years of age. It was concluded that men should be counselled regarding their dietary practices for the prevention of erectile dysfunction.

The main component of the MD is extra virgin olive oil (EVOO), widely known for its phenolic compounds that help in the prevention and treatment of many diseases. In this context, two new lines of research are proposed with olive oil: its effect on brown adipose tissue (BAT) and for the development of novel anti-cancer molecules based on the 3D modeling of oleacin (a phenolic compound found in EVOO). The first of these topics was studied in a clinical trial based on an EVOO consumption intervention. The results showed that the high monounsaturated fats present in EVOO increased BAT activity, leptin concentrations and other mediators of BAT activity. Conversely, an in-vitro study of phenolic compounds of EVOO developed four molecules with anticarcinogenic effects attributed to the physicochemical properties of oleacein. From this study, the candidate molecules mimicked the anti-cancer stem cell properties of oleacein, which has antiproliferative properties against cancerous cells. As is evidenced by these new lines of research, all the health properties of EVOO and the Mediterranean diet have not been fully investigated. However, the potential for EVOO’s applicability in other fields of health research is promising.