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Mediterranean-Style Diet for the Primary and Secondary Prevention of Cardiovascular Disease: A Cochrane Review.

Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial.
Adipocytokines and inflammatory biomarkers on blood pressure in adolescents: A longitudinal analysis.

Mediterranean diet and endothelial function in patients with coronary heart disease: An analysis of the CORDIOPREV randomized controlled trial.

Association between adherence to the Mediterranean diet and the prevalence of cardiovascular risk factors.

Mediterranean diet and endothelial function in patients with coronary heart disease: An analysis of the CORDIOPREV randomized controlled trial

Association Between Dietary Flavonoids Intake and Cognitive Function in an Italian Cohort.
"Influence of diet on mood and social cognition: a pilot study".

Lifestyle Risk Factors and Cognitive Outcomes from the Multidomain Dementia Risk Reduction Randomized Controlled Trial, Body Brain Life for Cognitive Decline (BBL-CD).

Preventive Role of Diet Interventions and Dietary Factors in Type 2 Diabetes Mellitus: An Umbrella Review.

Obesity Measures and Dietary Parameters as Predictors of Gut Microbiota Phyla in Healthy Individuals.

Impact of a Moderately Hypocaloric Mediterranean Diet on the Gut Microbiota Composition of Italian Obese Patients.

Antiviral Functional Foods and Exercise Lifestyle Prevention of Coronavirus.

Are olive pomace powders a safe source of bioactives and nutrients?

Mediterranean diet: knowledge and adherence in Italian young people.

A Quantitative Phytochemical Comparison of Olive Leaf Extracts on the Australian Market.

Bisphenol-A in the European Prospective Investigation into Cancer and Nutrition cohort in Spain: Levels at recruitment and associated dietary factors.

Mediterranean diet and risk of rheumatoid arthritis: findings from the French E3N-EPIC cohort study.

Higher Adherence to the Mediterranean Diet Is Associated With Preserved White Matter Integrity and Altered Structural Connectivity.

Mediterranean diet and health: A systematic review of epidemiological studies and intervention trials.

Gaussian Graphical Models Identified Food Intake Networks among Iranian Women with and without Breast Cancer: A Case-Control Study.

A nationwide assessment of lifestyle medicine counseling: knowledge, attitudes, and confidence of Israeli senior family medicine residents.


There is a global consensus that diet is a primary actor for health promotion worldwide, therefore, initiatives in this sphere should also align with environmental preservation. There is an enormous number of experimental and clinical studies related to the Mediterranean diet and its components in relation to cardiovascular disease in particular. In a cross-sectional study carried out in a Mediterranean cohort of 23,729 workers, 51.3% of the participants showed good adherence to the Mediterranean diet. The participants’ age was correlated with higher prevalence of abdominal obesity, overweight/obesity, diabetes, arterial hypertension and metabolic syndrome. The adjusted multivariate analysis showed a significant and inverse association between an acceptable Mediterranean diet adherence (>9/14 points) and the prevalence of central obesity, dyslipidemia and metabolic syndrome.

On the other hand, endothelial function is a key factor for the development of atherosclerosis and predictive of cardiovascular disease severity and recurrence. Despite the biological plausibility of protecting endothelium function through diet, there is still no consensus on a single recommended dietary pattern. An analysis of the CORDIOPREV randomized controlled trial has proposed the Mediterranean diet for its impact on endothelial function compared to a low-fat diet. The results suggest that it was associated with vascular homeostasis, even for patients with severe endothelial dysfunction.

Genetic and lifestyle factors, especially diet, are significant determinants of type 2 diabetes. Data from systematic reviews and meta-analyses of randomized controlled trials suggest that diet quality (low calories and low-fat diet) and/or enhanced level of physical activity can delay or prevent the onset of type 2 diabetes. The data comes from an umbrella review that comprised a total of 60 reviews and meta-analysis of diet and type 2 diabetes showed that healthy dietary patterns such as Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets, as well as a high consumption of whole grains, low-fat dairy products, yogurt, olive oil, chocolate, fiber, magnesium, and flavonoid significantly reduced the risk of type 2 diabetes.
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